Monoklonální gamapatie

The monoclonal gammopathies are a group of disorders associated with proliferation of clonal plasma cells producing monoclonal immunoglobulin proteins. Assessing serum levels of monoclonal proteins is an essential component of detecting and monitoring plasma cell proliferative disorders. The first part of this thesis provides a general overview that covers diagnosis and clinical features of some of the monoclonal gammopathies, particularly multiple myeloma. The second part was focused on investigating the utility of serum free light chains measurement in following the disease course in myeloma patients where monoclonal intact immunoglobulin was also present