A study of the compaction process and the properties of tablets made of spray dried lactoses

The aim of this work was to compare two spray-dried lactoses Flowlac® 100 and SuperTab® 14SD from the standpoint of tensile strength and disintegration time of tablets, the effect of an addition of the lubricant magnesium stearate and silicified microcrystalline celulose (Prosolv® SMCC 90) on these properties, and also from standpoint of the energy profile of compression. The compression forces were 15, 16, 17 kN, in the case of mixtures with Prosolv® SMCC 90. The concentration of magnesium stearate was 0.5% and 1% and the concentration of Prosolv® SMCC 90 was 25%. The tablets were prepared using the material testing equipment T1-FRO50 TH.S1K Zwick/Roell. The tablets from SuperTab® 14SD were stronger than the tablets from FlowLac® 100 at the same compression forces. Influence of magnesium stearate depended on the compression force in the case of SuperTab® 14SD. The presence of magnesium stearate did not decrease the strength of tablets from Flowlac® 100. The addition of Prosolv® SMCC 90 increased the strength of tablets and made it equal for both lactoses. Disintegration time of tablets from both lactoses did not depend on the compression forces. An increased concentration of magnesium stearate prolonged the disintegration time of the tablets, in the case of FlowLac® 100 very significantly. The..