Cytochromes P450 form a large family of hemoproteins. Some of them are responsible for the metabolism of endogenous substrates, but their major role is in detoxification of exogenous substrates (xenobiotics), some of them are activated to reactive species forming covalent adducts with DNA and increasing intracellular oxidative stress. Cytochrome P450 are considered by very promiscuous in terms of their substrate specificity, thus one enzyme can typically oxidize many substrates. Cytochrome P450 1A1 prefers a planar aromatic compounds (e.g. polycyclic aromatic hydrocarbons, azo dyes, etc.). Cytochrome P450 1A2 elicits similar substrate specificity, but prefers slightly basic aromatic derivatives, for example caffeine. This work focuses on (i...
Human cytochrome P450 (P450) enzymes metabolize a variety of endogenous and xenobiotic compounds, in...
Human cytochromes P450 2S1 and 2W1 have received only limited attention with regard to characterizat...
Cytochrome P450s play a central role in the metabolism and disposition of an extremely wide range of...
Cytochromes P450 are heme enzymes with very broad substrate specificity, they can oxidize tens to hu...
The thesis was worked out in Laboratory of Molecular Carcinogenesis and Drug Development, which is f...
The thesis was worked out in Laboratory of Molecular Carcinogenesis and Drug Development, which is f...
Human cytochrome P450 (P450) 1B1 was expressed in Escherichia coli at a level of 200 nmol/liter cult...
Human cytochrome P450 (P450) 1A1 is primarily an extrahepatic enzyme and is important because of its...
Human cytochrome P450 (P450) 2E1 is of interest because of its role in the oxidation of numerous dru...
Study of carcinogenesis is associated with study of xenobiotics metabolism, which is topic studied i...
Study of carcinogenesis is associated with study of xenobiotics metabolism, which is topic studied i...
Human cytochrome P450 (P450) 1B1 was expressed in Escherichia coli at a level of 200 nmol/liter cult...
Human cytochrome P450 (P450) 1B1 was expressed in Escherichia coli at a level of 200 nmol/liter cult...
Heterologous expression systems can be utilized to great advantage in the study of cytochrome P450 (...
Cytochrome P450 1A1 belongs to "superfamily" of cytochromes P450 (CYPs). It is an extrahepatic enzym...
Human cytochrome P450 (P450) enzymes metabolize a variety of endogenous and xenobiotic compounds, in...
Human cytochromes P450 2S1 and 2W1 have received only limited attention with regard to characterizat...
Cytochrome P450s play a central role in the metabolism and disposition of an extremely wide range of...
Cytochromes P450 are heme enzymes with very broad substrate specificity, they can oxidize tens to hu...
The thesis was worked out in Laboratory of Molecular Carcinogenesis and Drug Development, which is f...
The thesis was worked out in Laboratory of Molecular Carcinogenesis and Drug Development, which is f...
Human cytochrome P450 (P450) 1B1 was expressed in Escherichia coli at a level of 200 nmol/liter cult...
Human cytochrome P450 (P450) 1A1 is primarily an extrahepatic enzyme and is important because of its...
Human cytochrome P450 (P450) 2E1 is of interest because of its role in the oxidation of numerous dru...
Study of carcinogenesis is associated with study of xenobiotics metabolism, which is topic studied i...
Study of carcinogenesis is associated with study of xenobiotics metabolism, which is topic studied i...
Human cytochrome P450 (P450) 1B1 was expressed in Escherichia coli at a level of 200 nmol/liter cult...
Human cytochrome P450 (P450) 1B1 was expressed in Escherichia coli at a level of 200 nmol/liter cult...
Heterologous expression systems can be utilized to great advantage in the study of cytochrome P450 (...
Cytochrome P450 1A1 belongs to "superfamily" of cytochromes P450 (CYPs). It is an extrahepatic enzym...
Human cytochrome P450 (P450) enzymes metabolize a variety of endogenous and xenobiotic compounds, in...
Human cytochromes P450 2S1 and 2W1 have received only limited attention with regard to characterizat...
Cytochrome P450s play a central role in the metabolism and disposition of an extremely wide range of...