Studies on immunoreceptor signaling molecules

A delicate balance in the number, specific type and function of leukocytes is required for proper functionality of the mammalian immune system. Innate immunity, which quickly recognizes pathogens, represents the first line of defense. Later, a more specific response is generated via adaptive immunity. Deregulation of the immune system is manifested by the inability to control infection, development of allergic, autoimmune disorders or even cancer, and ultimately can lead to death. To fulfill their functions, cells develop an intricate network of intra- as well as extra-cellular molecules organized into signaling cascades, which allows them to communicate between each other. Better understanding of the molecular mechanisms of signaling pathways in leukocytes is critical for design of efficient therapies. In this thesis, leukocyte signaling was studied in several aspects. First, the role of adhesion molecules in pathogenesis of cervical cancer and the regulation of their expression was investigated. The second publication describes a new transmembrane adaptor protein (TRAP), called prolin rich 7 (PRR7), as a potentially interesting regulator of signaling and apoptosis in activated T cells. The final publication characterized the role of the Btk kinase downstream of the triggering receptor expressed..