Nanofibre membranes as drug carriers 7.

Thesis in the theoretical part provides a summary of basic information about the formation and properties of nanofibers and nanofibre membranes, briefly acquainted with natural and synthetic polymers suitable for the formation of nanofibers and gives an overview of the properties of the two drugs suitable for processing into nanofibers. The mean in vitro flux J of caffeine as a marker of sublingual membrane integrity is about 445 ± 30 [μg/cm2 .hod 1 ]. The mean amount of sumatriptan released within 5 minutes and 60 minutes from the nanofibr membranes tested in pH 7.4 phosphate buffer and in artificial salivary fluid was at about 75%, respectively. 80% of the total amount contained drugs. The analogous values of the newly studied substances API1 are of about only a half. The values of in vitro J fluxes API1 through sublingual membrane were obtained for the two different carrier nanofiber chitosan membranes and are 5.8 ± 0.3 [μg/cm2 .hod 1 ] and 6.8 ± 1.45 [μg/cm2 .hod 1 ] respectively