Osmolality of parenteral preparations. Potassium phosphate.

Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of: Department of Pharmaceutical Technology Consultant: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Martina Pavelková Title of Thesis: Osmolality of parenteral preparations. Potassium phosphate. In this work the density and osmolality of aqueous solutions of potassium dihydrogen phosphate was measured in the a concentration range from 0.02 to 1.0 mol/kg and/or mol/l, respectively. When increasing the temperature in the a range from 15řC to 40řC density decreased but the relationship was not linear. At constant temperature the density was directly proportional to the concentration of solution. The dependence between concentration and osmolality was described by a quadratic regression with the coefficient of determination 0.9997 for molal and molar solutions. The solution density at 25řC was used for mutual conversion between the molarity and molality and for estimation of the osmolarity in accordance to USP. Out of three studied methods the most accurate method of osmolarity estimation was the method utilizing the partial specific volume of the solute, which slightly increasinged when a concentration of the solution increased. For potassium dihydrogen phosphate, the mean partical specific volume of 0.31 ml/g could be..