Current possibilities of asthma therapy

Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of farmacology and toxicology Jana Košková Supervisor: PharmDr. Marie Vopršalová, CSc. Title of diploma thesis: Current possibilities of treatment of asthma The asthma is a chronic inflammatory disease of respiratory ways, which affects a significant proportion of global population and its prevalence is increasing. Together with inflammation, bronchial hyperreactivity and intermittent obstruction of respiratory ways are involved in the iniciation and development of asthma. Asthma is caused not only by the genetic predisposition, but also by the environment and current lifestyle. The repeated states of breathlessness, wheeze on chest, feel of pressure on chest and cough are the typical the clinical symptoms of the clinical picture. These problems occur frequently at night and early in the morning. Classification based on seriousness of clinical status before treatment divides the asthma for intermittent, mild persistent, moderate persistent and severe persistent. A new approach to the asthma resulted to the changes in pharmacotherapy. The important change was determination of drugs, which will be used to treatment of the acute attacks of asthma and preventive drugs for long-term regular use. Inhalation corticosteroids..