Alkaloids of plants from family Amaryllidaceae and their biological activiy (1960-2010)

Buková, V. Alkaloids of plants from family Amaryllidaceae and their biological activity (1960-2010). Charles University in Prague, Faculty of Pharmacy in Hradec Králové, 77 pp. The Amaryllidaceae family includes many species with important biological effects. This thesis is concerned with alkaloids of this family, their chemical structure, occurrence in particular species. Main goal of this thesis is to introduce their biological effects. The most important alkaloid of this family - galanthamin - acts as ecetylcholinesterase inhibitor and it is utilized for treating of the Alzheimer disease. The inhibitory effect on acetylcholinesterase has been described also at lycorin, 1-O-acetyllycorin, ungerenin, deoxylycorenin, montanin, hamayn and sanguinin. Amaryllidaceae alkaloids have also strong anticancer effects; an activity has been proved especially at alkaloids lycorin, pseudolycorin, pancratistatin, narciclasin, crinamin, heamanthamin, and others. From other important effects, it is necessary to mention antiprotosoal, antivirotic, antitrypanosomal, antibacterial, antiphlogistic, and antifungal activities