Suppositories in current therapy I

Suppositories are a conventional dosage form. Although their research is not being developed much further, there are still some changes to be found. Some new adjuvants have been used, the old active substances have been deleted and replaced by new ones. The last survey of rectal preparations was created in 1998. This paper provides an overview of proprietary rectal and vaginal suppositories, which were available on the market in 2010. There is a list of such products, medicinal substances used and their percentage. There are adjuvants and packaging materials, too. We found values of the melting temperature of those suppositories, which were stored under different conditions. These values were correlated to times of deformation of the preparations. On the basis of the evaluated data we recommend monitoring of changes in the melting temperature and the time of deformation of the products DICLOREUM 100 and KETONAL