Contribution to the formulation of polyester nanoparticles with terbinafine

Charles Univerzity in Prague Faculty Of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Candidate: Barbora Sulíková Consultant: Doc. RNDr. Milan Dittrich, CSc. Title of thesis: Contribution to the formulation of polyester nanoparticles with terbinafine In the theoretical part of this thesis are published some basic information concerning some aspects of nanotechnology as perspective field of human activity, indicated main possibilities of the realisation of nanotechnological methods used for ameliorating the pharmacotherapy efficiency, described nanoparticulate systems used as drug carriers, and also presented for the praxis valuable methods of nanoparticles preparation with relevancy for the eventual production in the future. The experimental part of the thesis refers about granulometric characterisation of nanoparticles prepared from terpolymer of DL-lactic acid, glycolic acid, and tripentaerythritol by the emulsion- solvent distribution method via emulsion of the o/w type. The reason of the nanoparticles selection was in the use of them as potential carrier for prolongation of liberation or targeting of antimycotic drug terbinafine. The experimental variables selected as studied factors was concentration of polymeric carrier, concentration of the base of terbinafine in the..