Prevention of cervical cancer

Cancer of the cervix is the third most common gynecological cancer diseases in the Czech Republic and is the second leading cause of death from malignant consequences disease in women aged 15-44 years in Europe. The Czech Republic is cervical cancer throat diagnosed each year with approximately a thousand women, with almost 400 women in this disease die . The pathogenesis of this cancer is multifactorial , the essential role plays a persistent infection risk types of human papilloma virus, HPV , which is proven at about 3-5 % of women aged 35-40 years. Due to the frequent occurrence of this tumor disease for many years introduced secondary preventive screening, aimed at the detection of precancerous and early invasive breast forms , which are very good therapeutic influenced . Substantial progress in recent years is the possibility of primary prevention of these diseases using HPV vaccine viruses. Both vaccines available on the market are targeted against the two major types of HPV - types 16 and 18 are responsible for approximately 70 % of high grade cervical dysplasia and carcinoma in situ. The efficacy of these vaccines was observed in a number of randomized , placebo-controlled trials in which the demonstrated excellent immunogenicity leading to seroconversion in virtually all vaccinated people. Above..