název v anglickém jazyce není uveden

Adipocytokines are a group of adipose tissue-derived cytokines that have been discovered since early nineties. The role of selected adipocytokines in the prostate carcinoma and in selected joint diseases was evaluated. In the first part of this work the role of adiponectin and resistin in the prostate cancer development and progression was examined. Immunohistochemical expression and serum levels of these adipocytokines were evaluated in both groups of patients with benign prostate hyperplasia and prostate cancer of pathological grade pT2 and pT3, respectively. Moreover, selected metabolic, biochemical and anthropometric parameters were included into this study. Serum adiponectin levels did not differ between prostate benign hyperplasia and prostate cancer generally, but they were significantly higher in pT3 in comparison to pT2 group. In agreement with the results of serum levels, tissue immunohistochemistry showed enhanced staining intensity of adiponectin in neoplastic glands and to a lesser degree in prostatic intraepithelial neoplasia while within benign prostate hyperplasia the immunohistochemical staining was generally low. None relation of adiponectin expression to disease grade or stage was observed. In resistin no difference between benign hyperplasia and prostate cancer in respect to serum levels..