Nanofiber membranes as carriers of drugs 1. Chitosan, polyamide 6, polyurethane.

9. Abstract The theoretical part deals, in the introduction, with the questions of the transdermal administration of medicines and also with the current overview of the transdermal preparations registered by the FDA Agency (U.S. Food and Drug Administration). The basic principles of the non-woven fabric production technology focused on the electrospinning method, which is used in the production of nanofiber membranes and evaluated further in the experiment, are described. The next part is dedicated to the characteristics and production of polymers which compose the tested membranes. Some physical tests which were used for the continued characterization of the nanofiber membranes are shown. The first chapter of the experimental part gives the results of the three physical and technical characteristics of the nanofiber membranes produced by electrospinning, from chitosan, polyamide 6 and polyurethane. A piece of the samples from these polymeric non-woven nanomembranes was radiosterilized. From the tensile strength point of view the nanofiber membrane made of polyurethane fibres was the most stable. The radiation sterilization process caused the lessening of the strength of the nanomembrane made of chitosan, of the other two membranes the sterilization process had no significant influence. The membranes made..