A study of the properties of tablets from coprocessed dry binder composed of mannitol and sorbitol.

The thesis deals with the study of properties of tablet from directly compressible co-processed dry binder Compressol™S and from the mixtures of Mannogem™2080 and Sorbitab™SD 250 in the ratios 1:3, 1:1 and 3:1. The focus of the study was the dependence of the tensile strength and disintegration time of the tablets on the compression force, the addition of lubricants, namely magnesium stearate and sodium stearyl fumarate with concentration of 1% and addition of model active ingredients, namely acetylsalicylic acid and ascorbic acid in ratio 1:1 to dry binder. The tablets containing Compressol™S that were compressed with a force of 8 kN contained 0,5% of lubricants too. The used compression forces were 6, 8 and 10 kN, tablets containing drugs were only compressed with a force of 10 kN and only sodium stearyl fumarate as lubricant was used. The strength of tablets of Compressol™S increased with increasing compression force, it didn't decrease with increasing concentration of lubricants and more significant difference wasn't noted in the terms of lubricant used. The longer disintegration time was found for magnesium stearate. The tablets from the mixture of Mannogem™2080 and Sorbitab™SD 250 in the ratio of 1:3 were found as the hardest compared with other mixtures and the disintegration time was the..