Pharmacology of antidotes

1 1. Abstract Intoxications belongs to the group of serious conditions that threaten the health and lives of patients. In the introduction of the work is summarised the general treatment of intoxications. All the necessary emergency measures are more effective as sooner are applied. Treatment consists of both in the inactivation and elimination of toxic substances, and minimise the secondary damage and the development of complications. In prophylaxis of absorption of toxic substances are abandoned late lavage of the stomach, the best is to submit the charcoal (25-50 g ) in the form of a suspension as soon as possible after the ingestion of poison. Repeated administration of the charcoal after 4-5 hours is able to shorten the period of elimination of most substances. Forced diuresis is not a routine part of treatment. In serious cases of certain poisonings are indicated extracorporal elimination methods with leading edge of the hemodialysis. The administration of specific antidotes is indicated only in selected cases, but serious suspicion of poisoning with highly toxic substances is recommended to administer antidotes without laboratory confirmation of diagnosis. The work deals in details with some specific antidotes. For each substance are mentioned pharmacological properties, indications,..