HER2/neu and other markers in breast tumours.

2. SUMMARY Author: Bc. Lenka Celbová Tutor: MUDr. Jiří Hochmann, CSc. Title of a work: HER-2/neu and other markers in breast tumours Diploma work Department of Biological and Medical Sciences Charles University in Prague, Faculty of Pharmacy in Hradec Králové Study programme: Healthcare bioanalytics The aim of our diploma work is to bring an overview of the tumour marker HER- 2/neu especially with focus on its activation, laboratory detection, relation to hormonal receptors, its role in tumorgenesis of breast carcinoma and also on the examination of its prognostic importace and its relation to the breast cancer treatment. In the clinical part of this review work we target especially the prognostic and predictive value of HER-2/neu. In many studies, a bad prognosis of HER-2/neu positive breast cancer was confirmed. In this connection the importance of determination of extracellular domain HER-2/neu in serum was examined in the literature. It is proved, that observation of this parameter is useful for monitoring of the patients with HER-2/neu positive carcinomas and there is also proved its predictive importance for the trastuzumab treatment. Another topic investigated in this work is expression of HER-2/neu de novo. Two studies, we found, confirm the opinion, that an amplification of HER-2/neu de novo can..