Ecotoxicological study of the select drug

Dagmar Střílková, Ecotoxicologial study of the select drug, diploma work Charles University in Prague, Faculty of Pharmacy, Department of Pharmaceutical Botany and Ecology Ibuprofen, the effective substance of drug IBALGIN® 400 mg, belongs to widely used nonsteroidal antiinflammatory drugs. It is primary used to treat most of the inflammatory illnesses. The renal excreting is the most important way of the final elimination. Ibuprofen can get into surface, ground and drinking water. Because of the interpretation of the result for impact on enviroment, the acute toxicity of this pharmaceutical was evaluated on organism of all the trophic levels. The green alga S capricornutum was chosen like the representative of the procedurs, which is used in 72 hour growth inhibition test ALGALTOXKIT F. Crustacean T platyurus of the series of the consumers was used in 2 next tests. The mortality of the larva of this crustacean is found out by means of 24 hour test THAMNOTOXKIT F. RAPIDTOXKIT evaluates the inhibition of the food receiving by the crustacean. 2 tests were done on the representative of the decomposer, T pyriformis. PROTOXKIT F evaluates the growth inhibition of this ciliate. MTT bioassay is based on the reduction of tetrazolium salt (MTT) by the mitochondrial dehydrogenace of viable cells in formazan...