Synthetic studies on 2,3-disubstituted furan scaffold

There are only few ways leading to 2,3-disubstituted furanes. The aim of my thesis was to optimize method of preparation of these compounds. Two 2,3-disubstituted furanes and one 2,3,5-trisubstituted furane were prepared by palladium catalyzed cyclization of propargyl alkohols with methyl propiolate. All the products were tested for antifungal and antibacterial activity but they did not display any significant effect