Nanofiber membranes as carriers of drugs 2. Polyvinylalcohol, chitosan, (D,L) polylactic acid.

1. ABSTRACT Diploma thesis concerns with the evaluation of the basic properties of the nanofibre membranes that are made of polyvinylalcohol, chitosan and (D,L) polylactic acid in connection with their possible use as carriers of drugs. Thesis characterizes electrospinning as a method of production of nonwoven textiles and nanofibre materials, polymers that were used in preparation of the nanofibre membranes under experiments, and testing methods that were used. Transdermal pharmaceuticals declared in the AISLP database were summarized in the connection with their possible use in drug administration. The selected physical characteristics of three chemical types of the nonwoven nanofibre membranes made in laboratories ELMARCO Liberec were investigated. The tensile stress properties, hydrophile-lipophile character of surface and absorption-release properties of the membranes were studied at a permeation in vitro study using caffein as a model drug in the experimental part of my work. Tensile properties of membranes are affected by previous radiation sterilization and direction of testing. General characterization of all membranes was not found. Chitosan membrane becomes firmer material after sterilization and it is also tougher in transverse tensile force. PLA membrane is weak after sterilization and also..