Potentiometric determination of ibuprofen.

Potentiometric determination of ibuprofen Thesis Ivana Šrámková A development of a selective electrode for potentiometric determination of ibuprofen in pharmaceutical formulations was aimed in this work. Several sensors were constructed. Their response to the ibuprofen was under study. It was revealed that a choice of appropriate membrane components as well as the molar ratio of them is of high importance for an ibuprofen-selective sensor. Some of the tested sensor's response is close to the Nernstian response. The best results were achieved using HP-β-CD with the function of an ionophore, 2- phenyl-2-nitrophenyl ether as a solvent mediator and tetrahexylammonium bromide as lipophilic specie. It was found that one of the evaluated electrodes is potentially iodide- selective. The ibuprofen-selective electrode with the best features is still under study