Exprese a role P-glykoproteinu a BCRP transportního proteinu a karcinomu prsu

ABC (ATP-binding cassette) proteins form the largest known transporter gene family. P- gp and BCRP are so far the most described members of the ABC family that translocate a variety of endogenous as well as exogenous compounds including drugs across cellular compartments. In this way the transporters protect human healthy tissues from xenobiotic compounds which can impair structure or function of the tissue. In recent years, many studies have been done to find the correlation between the expression of ABC transporters in breast tumor cells and failure of the breast cancer therapy. It has been confirmed that P-gp and BCRP (two specific ABC transporters) are expressed in breast tumors in a higher degree and can be responsible for the decrease of cytotoxic drugs inside the cell leading to the noneffective therapy. Many modulators of P-gp and BCRP have been developed to inhibit transporter expression causing the subsequent sensivity to cytotoxic drugs. There are new perspective treatment strategies formed, such as the combination of chemotherapeutics with substances inhibiting and/or preventing drug resistance of cancer cells, that could be used in clinical practise in the future