Prevention of Diabetes Mellitus I. type in childhood

Type 1 diabetes mellitus is among autoimmune disease that primarily affects children and young people. when This disease leads to the destruction of B-cells Pancreatic islets of Langerhans which are responsible for insulin secretion. Its deficiency leads to disturbances metabolism of carbohydrates and other nutrients . The destruction of B- cells occurs gradually and the first clinical symptoms appear only when destruction of a percentage of B- cells of the pancreas . after the outbreak difficulties the patient becomes dependent on exogenous life insulin administration . The incidence of type 1 diabetes mellitus is increasing worldwide and There are significant differences between geographic countries. This suggests that the pathogenesis of the disease have undoubtedly a great influence environmental factors. important role Genetic factors also play a immunological mechanisms. In my work I try to outline the possibilities of prevention as it related prediction type 1 diabetes mellitus . describe primarily genetic , and immunological markers , which can be used to predict genetic risk and to monitor the period before the manifestation of the disease. I mention also the possibilities of primary prevention, which is not currently yet only at the experimental field. Within the secondary Prevention describes..