Add to ORKGDirected lithiation of substituted pyridines containing a directing metalating group (DMG) with a lithium reagent in anhydrous solvent at low temperature gives the corresponding lithium intermediates in-situ, which on reactions with electrophiles produce the corresponding substituted derivatives. The method is simple, general, convenient and often high yielding
Lithiation of N′-phenethyl-N,N-dimethylurea with three equivalents of tert-butyllithium in anhydrous...
Lithiation of various N′-aryl-N,N-dimethylureas takes different courses depending on the substituent...
Directed lithiation of various substituted benzylamines takes different courses depending on the sub...
Directed lithiation of substituted pyridines containing a directing metalating group (DMG) with a li...
Directed lithiation of substituted aromatics and heterocycles containing a directing metalating grou...
Lithiation of pyridines substituted in the 2- and 4-positions by acylaminomethyl groups, namely of t...
This review deals with directed and regioselective lithiation of various quinazoline derivatives by ...
International audienceHerein we report regioselective deprotonations of 3- and 4-(tetrahydropyran-2-...
Generally considered kinetic intermediates in addition reactions of alkyllithiums to pyridine, 1-lit...
Directed lithiation and substitution of various N-benzyl pivalamides and various N'-benzyl-N,N-dimet...
The use of diethyl ether–tetrahydrofuran–light petroleum (b.p. 30–40 °C)(4:3:1) as solvent for the r...
Various quinazolin-4(3H)-ones and quinazolines were successfully lithiated using different lithiatin...
Lithiation of N′-phenethyl-N,N-dimethylurea with three equivalents of tert-butyllithium in anhydrous...
Lithiation of various N′-aryl-N,N-dimethylureas takes different courses depending on the substituent...
Directed lithiation of various substituted benzylamines takes different courses depending on the sub...
Directed lithiation of substituted pyridines containing a directing metalating group (DMG) with a li...
Directed lithiation of substituted aromatics and heterocycles containing a directing metalating grou...
Lithiation of pyridines substituted in the 2- and 4-positions by acylaminomethyl groups, namely of t...
This review deals with directed and regioselective lithiation of various quinazoline derivatives by ...
International audienceHerein we report regioselective deprotonations of 3- and 4-(tetrahydropyran-2-...
Generally considered kinetic intermediates in addition reactions of alkyllithiums to pyridine, 1-lit...
Directed lithiation and substitution of various N-benzyl pivalamides and various N'-benzyl-N,N-dimet...
The use of diethyl ether–tetrahydrofuran–light petroleum (b.p. 30–40 °C)(4:3:1) as solvent for the r...
Various quinazolin-4(3H)-ones and quinazolines were successfully lithiated using different lithiatin...
Lithiation of N′-phenethyl-N,N-dimethylurea with three equivalents of tert-butyllithium in anhydrous...
Lithiation of various N′-aryl-N,N-dimethylureas takes different courses depending on the substituent...
Directed lithiation of various substituted benzylamines takes different courses depending on the sub...