The susceptibility of axons to blunt head injury is well established. However, axonal injury following cerebral ischemia has attracted less attention than damage in gray matter. We have employed immunocytochemical methods to assess the vulnerability of axons to cerebral ischemia in vivo. Immunocytochemistry was performed using antibodies to a synaptosomal-associated protein of 25 kDa (SNAP25), which is transported by fast anterograde transport; the 68-kDa neurofilament subunit (NF68kD); and microtubule-associated protein 5 (MAP5) on sections from rats subjected to 30 min and 1, 2, and 4 h of ischemia induced by permanent middle cerebral artery (MCA) occlusion. After 4 h of occlusion, there was increased SNAP25 immunoreactivity, which was bu...
Background and Purpose The effects of ischemia on the cerebral white matter structure seldom have be...
We raised polyclonal antibodies against components of sciatic nerves undergoing Wallerian degenerati...
Compelling evidence now points to the critical role of the cytoskeleton in neurodegeneration. In ...
The susceptibility of axons to blunt head injury is well established. However, axonal injury followi...
Axonal injury following cerebral ischaemia has attracted less attention than damage in grey matter. ...
Amyloid precursor protein (APP) is transported by fast anterograde axonal transport. Since disruptio...
Myelinated axons are essential for the normal functioning of the brain. Since myelinated axons, like...
The dementia of Alzheimer's type and brain ischemia are known to increase at comparable rates with a...
Axon injury and degeneration is a common consequence of diverse neurological conditions including mu...
Diffuse axonal injury (DAI) is a significant feature of traumatic brain injury (TBI) across all inju...
Traumatic brain injury (TBI) commonly results in primary diffuse axonal injury (DAI) and associated ...
Axon injury and degeneration is a common consequence of diverse neurological conditions including mu...
Axonal damage is a major factor contributing to disease progression in multiple sclerosis (MS) patie...
<p>(A) Representative photomicrographs of NeuN-immunopositive neurons (brown staining) in the cortic...
We have evaluated the spatial relationship between local blood flow and the structural integrity of ...
Background and Purpose The effects of ischemia on the cerebral white matter structure seldom have be...
We raised polyclonal antibodies against components of sciatic nerves undergoing Wallerian degenerati...
Compelling evidence now points to the critical role of the cytoskeleton in neurodegeneration. In ...
The susceptibility of axons to blunt head injury is well established. However, axonal injury followi...
Axonal injury following cerebral ischaemia has attracted less attention than damage in grey matter. ...
Amyloid precursor protein (APP) is transported by fast anterograde axonal transport. Since disruptio...
Myelinated axons are essential for the normal functioning of the brain. Since myelinated axons, like...
The dementia of Alzheimer's type and brain ischemia are known to increase at comparable rates with a...
Axon injury and degeneration is a common consequence of diverse neurological conditions including mu...
Diffuse axonal injury (DAI) is a significant feature of traumatic brain injury (TBI) across all inju...
Traumatic brain injury (TBI) commonly results in primary diffuse axonal injury (DAI) and associated ...
Axon injury and degeneration is a common consequence of diverse neurological conditions including mu...
Axonal damage is a major factor contributing to disease progression in multiple sclerosis (MS) patie...
<p>(A) Representative photomicrographs of NeuN-immunopositive neurons (brown staining) in the cortic...
We have evaluated the spatial relationship between local blood flow and the structural integrity of ...
Background and Purpose The effects of ischemia on the cerebral white matter structure seldom have be...
We raised polyclonal antibodies against components of sciatic nerves undergoing Wallerian degenerati...
Compelling evidence now points to the critical role of the cytoskeleton in neurodegeneration. In ...