Negative ion tandem mass spectrometry (MS/MS) spectra of three isomeric triantennary N-linked glycans provided clear differentiation between the isomers and confirmed the occurrence of an isomer that was substituted with galactose on a bisecting GlcNAc (1→4-substituted on the core mannose) residue recently reported by Takegawa et al. from N-glycans released from human immunoglobulin G (IgG). We extend this analysis of human serum IgG to reveal an analogue of the fucosylated triantennary glycan reported by Takegawa et al. together with a third compound that lacked both the sialic acid and the fucose residues. In addition, we demonstrate the biosynthesis of bisected hybrid-type glycans with the galactose modification, with and without core fu...
To characterize the structures of N-glycans derived from human serum, we report a strategy that comb...
Sialic acids have diverse biological roles, ranging from promoting up to preventing protein and cell...
Protein N-glycosylation is a multifactorial process involved in many biological processes. A broad r...
Negative ion tandem mass spectrometry (MS/MS) spectra of three isomeric triantennary N-linked glycan...
Negative ion collision-induced dissociation (CID) of underivatized N-glycans has proved to be a simp...
Changes in the abundance of antennary fucosylated glycans in human total plasma N-glycome (TPNG) hav...
Introduction Congenital disorders of glycosylation (CDG) are among the inherited metabolic diseases ...
AbstractApplication of the negative mode electrospray ionization-quadrupole time-of-flight mass spec...
RATIONALE Negative ion collision-induced dissociation (CID) spectra of N-glycans contain many diagno...
<p>N-glycan structures of an IgG<sub>1</sub> antibody expressed in <i>Tnao</i>38 (A) and Hi5 (C) cel...
RATIONALE: Negative ion collision-induced dissociation (CID) spectra of N-glycans contain many diagn...
Glycomic profiling methods were used to determine the effect of metabolic inhibitors on glycan produ...
All immunoglobulin G molecules carry N-glycans, which modulate their biological activity. Changes in...
Glycosylated human IgG contains fucosylated biantennary N-glycans with different modifications inclu...
A mammalian N-acetylglucosamine (GlcNAc) transferase I (GnT I)-independent fucosylation pathway is r...
To characterize the structures of N-glycans derived from human serum, we report a strategy that comb...
Sialic acids have diverse biological roles, ranging from promoting up to preventing protein and cell...
Protein N-glycosylation is a multifactorial process involved in many biological processes. A broad r...
Negative ion tandem mass spectrometry (MS/MS) spectra of three isomeric triantennary N-linked glycan...
Negative ion collision-induced dissociation (CID) of underivatized N-glycans has proved to be a simp...
Changes in the abundance of antennary fucosylated glycans in human total plasma N-glycome (TPNG) hav...
Introduction Congenital disorders of glycosylation (CDG) are among the inherited metabolic diseases ...
AbstractApplication of the negative mode electrospray ionization-quadrupole time-of-flight mass spec...
RATIONALE Negative ion collision-induced dissociation (CID) spectra of N-glycans contain many diagno...
<p>N-glycan structures of an IgG<sub>1</sub> antibody expressed in <i>Tnao</i>38 (A) and Hi5 (C) cel...
RATIONALE: Negative ion collision-induced dissociation (CID) spectra of N-glycans contain many diagn...
Glycomic profiling methods were used to determine the effect of metabolic inhibitors on glycan produ...
All immunoglobulin G molecules carry N-glycans, which modulate their biological activity. Changes in...
Glycosylated human IgG contains fucosylated biantennary N-glycans with different modifications inclu...
A mammalian N-acetylglucosamine (GlcNAc) transferase I (GnT I)-independent fucosylation pathway is r...
To characterize the structures of N-glycans derived from human serum, we report a strategy that comb...
Sialic acids have diverse biological roles, ranging from promoting up to preventing protein and cell...
Protein N-glycosylation is a multifactorial process involved in many biological processes. A broad r...