Abstract In DSM-5, “autism spectrum disorder” (ASD) is a new diagnostic category effectively replacing the previous category of “autism”. In this paper I question whether either effectively represents a psychological natural kind with significant scientific and explanatory value. Despite the new categorisation, “ASD” and “autism” are effectively synonymous, and current understandings of ASD are based largely on previous research focussed specifically on autism. However, there has been no stable consensus over the past 40 years about what autism actually is. No biological explanation has been discovered, and no single psychological theory can account for the heterogeneity of autistic symptoms. A recent large-scale population-based study fail...