Increased expression of advanced glycation end-products and their receptor, and activation of nuclear factor kappa-B in lacrimal glands of diabetic rats.
- Alves, M.-P.
- Calegari, V C
- Andrade Da Cunha, Daniel
- Saad, M J A
- Velloso, L A
- Rocha, Eduardo M
Publication date
December 2005
DOI Publisher
Springer Science and Business Media LLC ISSN
0012-186X Citation count (estimate)
41Abstract
To assess the involvement of the AGE-specific receptor (AGER, also known as RAGE) axis and nuclear factor kappa-B (NFKB, also known as NF-kappaB) activation in the development of lacrimal gland and tear film dysfunction in diabetes, the present study evaluated: (1) lacrimal gland and tear film alterations in diabetic rats; and (2) the expression of AGE, AGER and NFKB in ocular tissues of normoglycaemic and diabetic rats.Journal ArticleResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe
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