Nanoparticles for targeting the infarcted heart

Author's Manuscript: 2012 October 12.We report a nanoparticulate system capable of targeting the heart after myocardial infarction (MI). Targeting is based on overexpression of angiotensin II type 1 (AT1) receptor in the infarcted heart. Liposomes 142 nm in diameter were conjugated with a ligand specific to AT1. The nanoparticles were able to specifically target cardiac cells in vitro, and in the infarcted heart after intravenous injection in vivo. This system may be useful for delivering therapeutic agents specifically to the infarcted heart.National Institutes of Health (U.S.) (Grant EB000244)National Institutes of Health (U.S.) (Grant EB006365)National Institutes of Health (U.S.) (Grant HL 086967)National Institutes of Health (U.S.) (Grant GM073626)American Heart Association (Postdoctoral Fellowship)Misrock Foundation (Postdoctoral Fellowship