The first enantioselective total synthesis of fidaxomicin, also known as tiacumicin B or lipiarmycin A3, is reported. This novel glycosylated macrolide antibiotic is used in the clinic for the treatment of Clostridium difficile infections. Key features of the synthesis involve a rapid and high-yielding access to the noviose, rhamnose, and orsellinic acid precursors; the first example of a β-selective noviosylation; an effective Suzuki coupling of highly functionalized substrates; and a ring-closing metathesis reaction of a noviosylated dienoate precursor. Careful selection of protecting groups allowed for a complete deprotection yielding totally synthetic fidaxomicin
The macrocyclic antibiotic mangrolideA has been described to exhibit potent activity against a numbe...
The macrolide class of antibiotics has been widely used to treat bacterial infections for over 65 ye...
The first total synthesis of the potent antibiotic disciformycin B (2) is described, which is except...
The first enantioselective total synthesis of fidaxomicin, also known as tiacumicin B or lipiarmycin...
The first enantioselective total synthesis of fidaxomicin, also known as tiacumicin B or lipiarmycin...
The commercial macrolide antibiotic fidaxomicin was synthesized in a highly convergent manner. Salie...
Fidaxomicin, also known as tiacumicin B or lipiarmycin A3, is a novel macrocyclic antibiotic that is...
Fidaxomicin (1, lipiarmycin A3, clostomicin B1, tiacumicin B) constitutes a glycosylated 18-membered...
The commercial macrolide antibiotic fidaxomicin was synthesized in a highly convergent manner. Salie...
The glycoslated macrocyclic antibiotic fidaxomicin (1, tiacumicin B, lipiarmycin A3) displays good t...
This thesis is divided into two chapters, describing two organic chemistry projects, both born from ...
The glycoslated macrocyclic antibiotic fidaxomicin (1, tiacumicin B, lipiarmycin A3) displays good t...
Fidaxomicin (FDX) is a marketed antibiotic for the treatment of Clostridioides difficile infections ...
Fidaxomicin (1, tiacumicin B, lipiarmycin A3) is a marketed antibiotic that is used in the treatment...
The natural product antibiotic fidaxomicin is a marketed drug for the treatment of bacterial infecti...
The macrocyclic antibiotic mangrolideA has been described to exhibit potent activity against a numbe...
The macrolide class of antibiotics has been widely used to treat bacterial infections for over 65 ye...
The first total synthesis of the potent antibiotic disciformycin B (2) is described, which is except...
The first enantioselective total synthesis of fidaxomicin, also known as tiacumicin B or lipiarmycin...
The first enantioselective total synthesis of fidaxomicin, also known as tiacumicin B or lipiarmycin...
The commercial macrolide antibiotic fidaxomicin was synthesized in a highly convergent manner. Salie...
Fidaxomicin, also known as tiacumicin B or lipiarmycin A3, is a novel macrocyclic antibiotic that is...
Fidaxomicin (1, lipiarmycin A3, clostomicin B1, tiacumicin B) constitutes a glycosylated 18-membered...
The commercial macrolide antibiotic fidaxomicin was synthesized in a highly convergent manner. Salie...
The glycoslated macrocyclic antibiotic fidaxomicin (1, tiacumicin B, lipiarmycin A3) displays good t...
This thesis is divided into two chapters, describing two organic chemistry projects, both born from ...
The glycoslated macrocyclic antibiotic fidaxomicin (1, tiacumicin B, lipiarmycin A3) displays good t...
Fidaxomicin (FDX) is a marketed antibiotic for the treatment of Clostridioides difficile infections ...
Fidaxomicin (1, tiacumicin B, lipiarmycin A3) is a marketed antibiotic that is used in the treatment...
The natural product antibiotic fidaxomicin is a marketed drug for the treatment of bacterial infecti...
The macrocyclic antibiotic mangrolideA has been described to exhibit potent activity against a numbe...
The macrolide class of antibiotics has been widely used to treat bacterial infections for over 65 ye...
The first total synthesis of the potent antibiotic disciformycin B (2) is described, which is except...