© 2016 PEI, University of Maribor. All rights reserved. Facility layout problem (FLP) is one of well-known NP-hard problems and has been demonstrated to be useful in enhancing the productivity of manufactur-ing systems in practice. This paper focuses on the unequal-area FLP (UA-FLP) whose goal is to locate departments with different areas within a given facility so as to minimize the total material handling cost. A novel approach, which we call a combined zone-linear programming (zone-LP) and simulated annealing algorithm, is developed for solving the UA-FLP. The zone-LP approach is a layout construction technique for the unequal-area departments and consists of two phases. In the first phase, a zoning algorithm is implemented to deter-min...