Bone morphogenetic proteins (BMPs) play roles in promoting cell anabolism, especially in extracellular matrix production. The difference between BMP members in their capacity to modulate intervertebral disc cell activity is yet to be defined. BMP-7/OP-1 has been shown to retard disc degeneration. We compared the activity of BMP-7 with that of BMP-2 on nucleus pulposus (NP) cell phenotype and function, and investigated how they differentially affect the gene expression profiles of signaling cascade components in human NP cells under degenerative states. We found that while both BMP-2 and BMP-7 enhanced matrix production of bovine NP cells, BMP-7 is more potent than BMP-2 at various dosages (50-800 ng/ml). BMP-7 exerted a relatively stronger ...
STUDY DESIGN: In vitro experiment using bone morphogenetic protein-2 (BMP-2) and human intervertebra...
Chronic back pain is related to intervertebral disc (IVD) degeneration and dogs are employed as anim...
Chronic back pain is related to intervertebral disc (IVD) degeneration and dogs are employed as anim...
Low back pain (LBP) is associated with intervertebral disc (IVD) degeneration and exerts enormous so...
Matrix production by nucleus pulposus (NP) cells, the cells residing in the center of the interverte...
Matrix production by nucleus pulposus (NP) cells, the cells residing in the center of the interverte...
Matrix production by nucleus pulposus (NP) cells, the cells residing in the center of the interverte...
STUDY DESIGN: In vitro experiment using bone morphogenetic protein-2 (BMP-2) and cells from the nucl...
Intervertebral disc (IVD) degeneration is the leading trigger of low back pain, which causes disabil...
Intervertebral disc (IVD) degeneration is the leading trigger of low back pain, which causes disabil...
Introduction: Loss of intervertebral disc (IVD) matrix and ultimately disc height as a result of 'de...
Low back pain (LBP) is a major health problem and one of the main sources of LBP is intervertebral d...
A hallmark of intervertebral disc degeneration is loss of proteoglycans. Cytokines may be used to st...
Objective—To assess therapeutic benefits for intervertebral disc matrix repair and regeneration, the...
Spinal fusion is hampered by the presence of remaining intervertebral disc (IVD) tissue and leads to...
STUDY DESIGN: In vitro experiment using bone morphogenetic protein-2 (BMP-2) and human intervertebra...
Chronic back pain is related to intervertebral disc (IVD) degeneration and dogs are employed as anim...
Chronic back pain is related to intervertebral disc (IVD) degeneration and dogs are employed as anim...
Low back pain (LBP) is associated with intervertebral disc (IVD) degeneration and exerts enormous so...
Matrix production by nucleus pulposus (NP) cells, the cells residing in the center of the interverte...
Matrix production by nucleus pulposus (NP) cells, the cells residing in the center of the interverte...
Matrix production by nucleus pulposus (NP) cells, the cells residing in the center of the interverte...
STUDY DESIGN: In vitro experiment using bone morphogenetic protein-2 (BMP-2) and cells from the nucl...
Intervertebral disc (IVD) degeneration is the leading trigger of low back pain, which causes disabil...
Intervertebral disc (IVD) degeneration is the leading trigger of low back pain, which causes disabil...
Introduction: Loss of intervertebral disc (IVD) matrix and ultimately disc height as a result of 'de...
Low back pain (LBP) is a major health problem and one of the main sources of LBP is intervertebral d...
A hallmark of intervertebral disc degeneration is loss of proteoglycans. Cytokines may be used to st...
Objective—To assess therapeutic benefits for intervertebral disc matrix repair and regeneration, the...
Spinal fusion is hampered by the presence of remaining intervertebral disc (IVD) tissue and leads to...
STUDY DESIGN: In vitro experiment using bone morphogenetic protein-2 (BMP-2) and human intervertebra...
Chronic back pain is related to intervertebral disc (IVD) degeneration and dogs are employed as anim...
Chronic back pain is related to intervertebral disc (IVD) degeneration and dogs are employed as anim...