Pengaruh Pemberian Boraks Dengan Dosis Bertingkat Terhadap Perubahan Makroskopis Dan Mikroskopis Ginjal Tikus Wistar Selama 4 Minggu

Background :Borax or Natrium Tetraborat is a chemically compund which widely used in industries and research field mainly for preservative, buffer, and disinfectant. However nowadays many used borax as additive for food, this issue is a violation againts the BPOM regulation. Many research have conducted experiment on the effect of swallow borax towards kidney, but they are slightly any research about effect of oral formalin towards histopatological image of kidney.Aim: This research aimed to proof the effect of 4-weeks administered gradual dose of oral borax to the macroscopic and microscopic or wistar rat's kidneyMethod: Experimental study with post test only control group design. The sampel were 15 wistar rats which have already met and fullfulled inclusion and exclusion criteria were adaptefd for 7 days. After adaption wistar rats divided using simpel random sampling into 3 groups. K (control group) was not given borax, P1 was given 300mg/KgBW/day oral Borax; P2 was given 600mg/KgBw/day oral borax. After 4 weeks all kidney sample were taken to identified any changes in macroscopic and microscopic image of wistar rat's kidney. Data was described in table, picture, and statistical analyze using SPSS for windows 15.0Result : P2 showed the highest of total kidney tubulus cell damage. From Mann-Whitney test showed there are no significant difference on first landmark between K-P1 (p=0.086) and 2nd -3rd landmark between P1-P2 (p<0.05). On the Organ Weight Test showed no significant difference in all groups.Conclusion : There are microscopic changes on kidney tubulus that was given with 300mg/KgBW/day and 600mg/KgBw/day oral borax, and then on the control group found no pathological effect. The Weight test Showed no effect with giving oral borax, no macroscopic effect