Gambaran Histopatologik Testis Tikus Wistar (Rattus Norvegicus) Setelah Pemberian Monosodium Glutamate (MSG)

: Monosodium glutamate (MSG) is a sodium salt from glutamic acid which is currently very popular to be used as a food flavoring ingredient to stimulate appetite. The objective of the study to discover the histologic findings of wistar rats\u27 testicles after MSG administration. This was an experimental laboratoric study, using 20 wistar rats that has been divided into 4 groups. The negative control group is given standard pallet and drinking water for 40 days; it devided to 2 smaller groups, K1 and K2, each of the group was terminated on the 21st and 41st day. The intervention group was given MSG according to average consumption dose in Indonesia; it devided to two smaller groups, P1 and P2, each group was terminated on the 21st and 41st day. The result showed on group K1 and K2, a normal finding of seminiferous tubules, spermatogenic cell layer arrays, and interstitial cell density was found. On group P1, showed seminiferous tubules with decrease of spermatogenic cells development, causing the tubules compartment to appear vacant; the spermatogonia layers appeared sparse on basal membrane, and fewer interstitial cells. On group P2, the findings were not of much difference with group P1, but in this group, one testicle specimen showed calcification cells inside its seminiferous tubules was found. Conclusion: Administration of MSG according to average consumption dose in Indonesia causes decrease of seminiferous tubules\u27 diameter and decrease of the number of spermatogenic cells and interstitial cells