Pengaruh Pemberian Getah Bonggol Pisang (Musa Paradisiaca Var. Sapientum L. Kuntze. AAB) Terhadap Penyembuhan Luka Sayat Pada Kulit Tikus Wistar (Rattus Norvegicus)

: Wound healing can be assisted by modern and traditional medicine. Banana stem sap is often used as a herbal remedy for wounds. The sap of banana stem contains saponins, flavonoids, anthraquinone, quinone, lectin, and tannins that are expected to promote wound healing. This study was aimed to determine the effect of banana stem sap on incised wound of the skin of Wistar rats. This was an experimental laboratory study. A total of 21 Wistar rats (Rattus norvegicus) were used in this study; one was used to obtain a normal skin sample, and the others were divided into control groups (A1 and B1) and treated groups (A2 and B2), five rats in each group. A 1-cm-skin incision was made on the back of each rat in all groups. The wounds of group A1 and B1 were untreated. In group A2 and B2, the wounds were applied with 0,5 ml of banana stem sap (Musa paradisiaca var. sapientum L. Kuntze. AAB) twice a day. Macroscopic and microscopic examinations of the wounds were performed on day-5 (group A1 and A2) and day-14 (group B1 and B2). The results showed that, either macroscopically (wound area and crusting) or microscopically (crust, reepithelization, angiogenesis, proliferation of fibrous tissue and inflammatory cells), group A2 and B2 exhibited better wound healing compared with group A1 and B1. Conclusion: Better wound healing process in Wistar rats treated with banana stem sap on their insiced wounds compared to those that were untreated indicates that banana stem sap play distinct roles in promoting wound healing