The Effect of Mangosteen Rind Glucose Transport in Small Intestine Cell Membrane of Wistar Rats

Seven percent of the people in the United States have hyperglycemia, which a third of them are unaware with the condition. To prevent this from occurring, mangosteen rind can be taken as daily supplements. Itsfruit hull has been used as traditional medicine in Southeast Asia countries. The objective of this researchis to study the effect of mangosteen rind (Garcinia mangostana) on glucose transport across small intestinecell membrane of wistar rats. Perfusion method of mangosteen rind was used to carry out this experiment.Nine rats were used after overnight fasting. They were divided into three groups where each group received20%, 40% and 60% of mangosteen rind. Each rat received simple glucose solution as the control and glucosewith mangosteen rind infusion as the treatment. The sample was taken every 15 minutes for 1 hour from thesmall intestine and was measured using a spectrophotometer. The results were not statistically significant forall three different concentration of mangosteen rind. The mangosteen rind has inhibitory effect but it is notstatistically significant on glucose absorption across small intestine cell membrane. Further investigation isneeded to be done by using higher concentration of mangosteenrind infusion