Identifikasi Asam Mefenamat Dalam Jamu Rematik Yang Beredar Di Distrik Heram Kota Jayapura, Papua

Jamu is a traditional ingredient or ingredients in the form of plant material, animal, mineral materials, preparation sarian (galenik) or mixtures of these materials that have been used for generations to treatment based on experience. Mefenamic acid is one of the drugs known as NSAIDs (Non-steroidal Anti-Inflammatory Drugs), which is a derivative antranilat. Mefenamic acid has the chemical formula C15H15NO2 and contains not less than 98.0% and not more than 102.0% C15H15NO2, calculated on the dried substance. Mefenamic acid is an analgesic and anti-inflammatory drugs. Analgesics are drugs to relieve pain by increasing the pain threshold in the central nervous system without pressing consciousness, while the anti-inflammatory is a drug used to treat inflammation. This research is a descriptive survey. Object of this study is herbal preparation for rheumatic circulating in Heram District. Rheumatic jamu were obtained from herbal stores located in the District of Heram. Identification of mefenamic acid, in rheumatic jamu used Thin Layer Chromatography (TLC) method. All The sampel analized did not contain mefenamic Acid. The Rf value of the spots in each variation of mobile phase were observed. Mobile phase ethyl acetate: methanol: ammonia gave Rf value of 0.90; 0.16; and 0.37 for sample 1, sample 2, and mefenamic acid standart, respectively. Mobile phase chloroform : methanol gave Rf value of 0.34; 0.87; and 0.94 for sample 1, sample 2, and mefenamic acid standart. Mobile phase cyclohexane : chloroform: methanol: glassial acetic acid gave Rf value of 0.67; 0.86; 0.40 for sample 1, sample 2, and mefenamic acid standar, respectively. Key words: mefenamic acid, rheumatic jamu, Thin Layer Chromatography