Cortactin (CTTN) is a substrate of the Src kinase Lyn that is known to play an actin cytoskeletal regulatory role involved in cell migration and cancer progression following its phosphorylation at Y421. We recently demonstrated that Cortactin is overexpressed in patients with chronic lymphocytic leukaemia (CLL). This work was aimed at defining the functional role of Cortactin in these patients. We found that Cortactin is variably expressed in CLL patients both in the peripheral blood and lymph nodes and that its expression correlates with the release of matrix metalloproteinase 9 (MMP-9) and the motility of neoplastic cells. Cortactin knockdown, by siRNA, induced a reduction in MMP-9 release as well as a decrease of migration capability of ...
Chronic Lymphocytic Leukemia (CLL) demonstrates variable reactivity of the B cell receptor (BCR) to ...
Lymphocyte trafficking is orchestrated by chemokine and sphingosine 1-phosphate (S1P) receptors that...
Tumor cell motility and invasion is governed by dynamic regulation of the cortical actin cytoskeleto...
Cortactin, an actin binding protein and Lyn substrate, is up-regulated in several cancers and its le...
B-cell chronic lymphocytic leukemia (B-CLL) is the most common form of leukemia in adults. It is cha...
Cancer is a major cause of death in children worldwide, with B-lineage cell acute lymphoblastic leuk...
Cortactin is a cytoskeletal-remodeling adaptor protein, playing an oncogenic role in solid tumors. L...
Cortactin is frequently overexpressed in cancer cells, and changes of the levels of its tyrosine pho...
Chronic lymphocytic leukemia cells (CLL) migrate between the blood and lymphoid tissues in response ...
Cortactin is an F-actin binding protein that stabilizes F-actin networks and promotes actin polymeri...
Abnormalities of molecules involved in signal transduction pathways are connected to Chronic Lymphoc...
Cortactin, an F-actin binding protein, stabilizes F-actin networks and promotes actin polymerization...
Abstract Background The nucleation-promoting factor cortactin is expressed and promotes tumor progre...
Background: The most important adverse prognostic factor for laryngeal squamous cell carcinoma (LSCC...
B cell chronic lymphocytic leukemia (B-CLL) is a neoplastic disorder characterized by accumulation o...
Chronic Lymphocytic Leukemia (CLL) demonstrates variable reactivity of the B cell receptor (BCR) to ...
Lymphocyte trafficking is orchestrated by chemokine and sphingosine 1-phosphate (S1P) receptors that...
Tumor cell motility and invasion is governed by dynamic regulation of the cortical actin cytoskeleto...
Cortactin, an actin binding protein and Lyn substrate, is up-regulated in several cancers and its le...
B-cell chronic lymphocytic leukemia (B-CLL) is the most common form of leukemia in adults. It is cha...
Cancer is a major cause of death in children worldwide, with B-lineage cell acute lymphoblastic leuk...
Cortactin is a cytoskeletal-remodeling adaptor protein, playing an oncogenic role in solid tumors. L...
Cortactin is frequently overexpressed in cancer cells, and changes of the levels of its tyrosine pho...
Chronic lymphocytic leukemia cells (CLL) migrate between the blood and lymphoid tissues in response ...
Cortactin is an F-actin binding protein that stabilizes F-actin networks and promotes actin polymeri...
Abnormalities of molecules involved in signal transduction pathways are connected to Chronic Lymphoc...
Cortactin, an F-actin binding protein, stabilizes F-actin networks and promotes actin polymerization...
Abstract Background The nucleation-promoting factor cortactin is expressed and promotes tumor progre...
Background: The most important adverse prognostic factor for laryngeal squamous cell carcinoma (LSCC...
B cell chronic lymphocytic leukemia (B-CLL) is a neoplastic disorder characterized by accumulation o...
Chronic Lymphocytic Leukemia (CLL) demonstrates variable reactivity of the B cell receptor (BCR) to ...
Lymphocyte trafficking is orchestrated by chemokine and sphingosine 1-phosphate (S1P) receptors that...
Tumor cell motility and invasion is governed by dynamic regulation of the cortical actin cytoskeleto...