Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
- Wolpin, Brian M.
- Rizzato, Cosmeri
- Kraft, Peter
- Kooperberg, Charles
- Petersen, Gloria M.
- Wang, Zhaoming
- Arslan, Alan A.
- Beane Freeman, Laura
- Bracci, Paige M.
- Buring, Julie
- Canzian, Federico
- Duell, Eric J.
- Gallinger, Steven
- Giles, Graham G.
- Goodman, Gary E.
- Goodman, Phyllis J.
- Jacobs, Eric J.
- Kamineni, Aruna
- Klein, Alison P.
- Kolonel, Laurence N.
- Kulke, Matthew H.
- Li, Donghui
- Malats, N\ufaria
- Olson, Sara H.
- Risch, Harvey A.
- Sesso, Howard D.
- Visvanathan, Kala
- White, Emily
- Zheng, Wei
- Abnet, Christian C.
- Albanes, Demetrius
- Andreotti, Gabriella
- Austin, Melissa A.
- Barfield, Richard
- Basso, Daniela
- Berndt, Sonja I.
- Boutron Ruault, Marie Christine
- Brotzman, Michelle
- B\ufcchler, Markus W.
- Bueno De Mesquita, H. Bas
- Bugert, Peter
- Burdette, Laurie
- Campa, Daniele
- Caporaso, Neil E.
- Capurso, Gabriele
- Chung, Charles
- Cotterchio, Michelle
- Costello, Eithne
- Elena, Joanne
- Funel, Niccola
- Gaziano, J. Michael
- Giese, Nathalia A.
- Giovannucci, Edward L.
- Goggins, Michael
- Gorman, Megan J.
- Gross, Myron
- Haiman, Christopher A.
- Hassan, Manal
- Helzlsouer, Kathy J.
- Henderson, Brian E.
- Holly, Elizabeth A.
- Hu, Nan
- Hunter, David J.
- Innocenti, Federico
- Jenab, Mazda
- Kaaks, Rudolf
- Key, Timothy J.
- Khaw, Kay Tee
- Klein, Eric A.
- Kogevinas, Manolis
- Krogh, Vittorio
- Kupcinskas, Juozas
- Kurtz, Robert C.
- Lacroix, Andrea
- Landi, Maria T.
- Landi, Stefano
- Le Marchand, Loic
- Mambrini, Andrea
- Mannisto, Satu
- Milne, Roger L.
- Nakamura, Yusuke
- Oberg, Ann L.
- Owzar, Kouros
- Patel, Alpa V.
- Peeters, Petra H. M.
- Peters, Ulrike
- Pezzilli, Raffaele
- Piepoli, Ada
- Porta, Miquel
- Real, Francisco X
- Riboli, Elio
- Rothman, Nathaniel
- Scarpa, Aldo
- Shu, Xiao Ou
- Silverman, Debra T.
- Soucek, Pavel
- Sund, Malin
- Talar Wojnarowska, Renata
- Taylor, Philip R.
- Theodoropoulos, George E.
- Thornquist, Mark
- Tj\uf8nneland, Anne
- Tobias, Geoffrey S.
- Trichopoulos, Dimitrios
- Vodicka, Pavel
- Wactawski Wende, Jean
- Wentzensen, Nicolas
- Wu, Chen
- Yu, Herbert
- Yu, Kai
- Zeleniuch Jacquotte, Anne
- Hoover, Robert
- Hartge, Patricia
- Fuchs, Charles
- Chanock, Stephen J.
- Stolzenberg Solomon, Rachael S.
- Amundadottir, Laufey T.
DOIAbstract
We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 x 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 x 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 x 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 x 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 x 10(-14)). We also identified a locus at 8...
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