Add to ORKGAlpha-interferon (alpha-IFN) therapy is an effective agent in early chronic phase (ECP) chronic myeloid leukemia (CML), achieving hematologic control in the majority and major cytogenetic response (MCR) (reduction in Ph' +ve metaphases to <35%) in a substantial minority. Currently no pretreatment markers exist to ascertain likelihood of meaningful response. The site of breakpoint in M-bcr and relationship to prognosis is controversial. Studies have been hampered by variation in definition of breakpoint and difference in treatment protocols. In this study of ECP CML patients, Southern analysis and reverse transcription polymerase chain reaction (RT-PCR) were used to determine breakpoint location. Patients received (alpha-IFN (9 x 106 units/d...
Forty-eight patients with chronic myeloid leukemia (CML) in chronic phase (CP) were treated by autol...
INTRODUCTION: Normal immature hematopoietic progenitors are relatively well preserved in most patien...
The aim of this analysis was to evaluate the efficacy of alpha-interferon (alpha-IFN) regimens in la...
Ph chromosome occurs in nearly all patients with CML, and eliminating Ph-positive clone is a major t...
PURPOSE: To determine, in patients with Philadelphia chromosome (Ph)-positive chronic myelogenous le...
Achieving a complete cytogenetic response (CCgR) is a major target in the treatment of chronic myelo...
Background and Objectives. This study was aimed at examining major cytogenetic response (MCR) as a v...
Achieving a complete cytogenetic response (CCgR) is a major target in the treatment of chronic myelo...
Achieving a complete cytogenetic response (CCgR) is a major target in the treatment of chronic myelo...
BACKGROUND: Standard or conventional treatment of chronic myeloid leukemia (CML) had little effect o...
To determine the impact on minimal residual disease by switching to imatinib chronic phase chronic m...
The aim of this analysis was to evaluate the efficacy of alpha-interferon (alpha-IFN) regimens in la...
The degree of tumor load reduction as measured by cytogenetic response is an important prognostic fa...
Interferon-alpha may be better than cytotoxic drugs in the long-term management of patients with chr...
We treated 114 Ph'+ chronic myeloid leukemia (CML) patients, 105 of whom were in chronic phase (CP) ...
Forty-eight patients with chronic myeloid leukemia (CML) in chronic phase (CP) were treated by autol...
INTRODUCTION: Normal immature hematopoietic progenitors are relatively well preserved in most patien...
The aim of this analysis was to evaluate the efficacy of alpha-interferon (alpha-IFN) regimens in la...
Ph chromosome occurs in nearly all patients with CML, and eliminating Ph-positive clone is a major t...
PURPOSE: To determine, in patients with Philadelphia chromosome (Ph)-positive chronic myelogenous le...
Achieving a complete cytogenetic response (CCgR) is a major target in the treatment of chronic myelo...
Background and Objectives. This study was aimed at examining major cytogenetic response (MCR) as a v...
Achieving a complete cytogenetic response (CCgR) is a major target in the treatment of chronic myelo...
Achieving a complete cytogenetic response (CCgR) is a major target in the treatment of chronic myelo...
BACKGROUND: Standard or conventional treatment of chronic myeloid leukemia (CML) had little effect o...
To determine the impact on minimal residual disease by switching to imatinib chronic phase chronic m...
The aim of this analysis was to evaluate the efficacy of alpha-interferon (alpha-IFN) regimens in la...
The degree of tumor load reduction as measured by cytogenetic response is an important prognostic fa...
Interferon-alpha may be better than cytotoxic drugs in the long-term management of patients with chr...
We treated 114 Ph'+ chronic myeloid leukemia (CML) patients, 105 of whom were in chronic phase (CP) ...
Forty-eight patients with chronic myeloid leukemia (CML) in chronic phase (CP) were treated by autol...
INTRODUCTION: Normal immature hematopoietic progenitors are relatively well preserved in most patien...
The aim of this analysis was to evaluate the efficacy of alpha-interferon (alpha-IFN) regimens in la...