Three-component synthesis of substituted β-(trifluoromethyl)pyrroles via Grob cyclization of 1,1,1-trifluoro-3-nitrobut-2-ene with 1,3-dicarbonylic compounds and ammonia or primary amines

Korotaev, Vladislav Yu.
Barkov, Alexey Yu.
Kotovich, Ivan V.
Sosnovskikh, Vyacheslav Ya.

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Publication date

January 2012

DOI

10.1016/j.jfluchem.2012.03.012

Publisher

Elsevier BV

ISSN

0022-1139

Journal

Journal of Fluorine Chemistry

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Abstract

A variety of substituted β-(trifluoromethyl)pyrroles were easily synthesized in good yields by a one-pot, three-component Grob cyclization of 1,1,1-trifluoro-3-nitrobut-2-ene with 1,3-dicarbonyls (ethyl acetoacetate, acetylacetone, benzoylacetone) and ammonia or primary aliphatic amines. © 2012 Elsevier B.V. All rights reserved

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Three-component synthesis of substituted β-(trifluoromethyl)pyrroles via Grob cyclization of 1,1,1-trifluoro-3-nitrobut-2-ene with 1,3-dicarbonylic compounds and ammonia or primary amines

Abstract

Extracted data

Three-component synthesis of substituted β-(trifluoromethyl)pyrroles via Grob cyclization of 1,1,1-trifluoro-3-nitrobut-2-ene with 1,3-dicarbonylic compounds and ammonia or primary amines

Abstract

Extracted data

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