Comparative genomic analysis of three Leishmania species that cause diverse human disease
- Peacock, C.S.
- Seeger, K.
- Harris, D.
- Murphy, L.
- Ruiz, J.C.
- Quail, M.A.
- Peters, N.
- Adlem, E.
- Tivey, A.
- Aslett, M.
- Kerhornou, A.
- Ivens, A.
- Fraser, A.
- Rajandream, M.A.
- Carver, T.
- Norbertczak, H.
- Chillingworth, T.
- Hance, Z.
- Jagels, K.
- Moule, S.
- Ormond, D.
- Rutter, S.
- Squares, R.
- Whitehead, S.
- Rabbinowitsch, E.
- Arrowsmith, C.
- White, B.
- Thurston, S.
- Bringaud, F.
- Baldauf, S.L.
- Faulconbridge, A.
- Jeffares, D.
- Depledge, D.P.
- Oyola, S.O.
- Hilley, J.D.
- Brito, L.O.
- Tosi, L.R.O.
- Barrell, B.
- Cruz, A.K.
- Mottram, J.C.
- Smith, D.F.
- Berriman, M.
DOIAbstract
Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked conservation of synteny and identifies only approx200 genes with a differential distribution between the three species. L. braziliensis, contrary to Leishmania species examined so far, possesses components of a putative RNA-mediated interference pathway, telomere-associated transposable elements and spliced leader–associated SLACS retrotransposons. We show that pseudogene formation and gene loss are the principal forces shaping the different genomes. Genes that ...
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