p21Waf1/Cip1 plays central roles in proliferation, differentiation, and apoptosis. Alterations in the expression and subcellular localisation of p21 occur during several lung diseases but the roles of p21 in the lung epithelium are unknown. The effects of p21 on proliferation and apoptosis in mouse airway epithelial cells (AECs) were examined using p21-null mice. AECs isolated from p21-null mice had increased proliferation and apoptotic rates compared to AECs from wild-type mice. Alterations in the subcellular localization of the cell cycle regulatory proteins p27, PCNA, and p53 were also evident in p21−/− cells. The nuclear and cytoplasmic forms of p21 present in AECs were also examined. Full-length p21 (20 kDa) was detected in nuclear fra...
In order to clarify critical events during bronchial carcinogenesis, and to evaluate a possible prog...
P21(Waf1/Cip1) is a potent cyclin-dependent kinase inhibitor. As a downstream mediator of p53, p21(W...
The Aggregatibacteractinomycetemcomitans cytolethal distending toxin (Cdt) induces lymphocytes to un...
p21(Waf1/Cip1) plays central roles in proliferation, differentiation, and apoptosis. Alterations in ...
AbstractAirway epithelium alterations, including squamous cell metaplasia, characterize smokers with...
Because the asthmatic bronchial epithelium is characterized by widespread damage, we postulated that...
Throughout development cells make the decision to proliferate, arrest or die. Control of this proces...
The first cyclin dependent kinase inhibitor to be discovered was the p21 cdk interacting protein (a....
Loss of cell cycle control is characteristic of tumorigenesis. The protein p21 is the founding membe...
p21WAF1/Cip1 belongs to the Cip/Kip family of cyclin kinase inhibitors (CKI) (p21Waf1/Cip1, p27Kip1,...
The p53-inducible gene product p21WAF1/CIP1 plays a critical role in regulating the rate of tumor in...
The p53-regulated gene product p21WAF1/CIP1 is the prototype of a family of small proteins that nega...
p21(Waf1/Cipl) is a critical downstream effector in the p53-dependent pathway of growth control and ...
The effects of exogenous expression of p21WAF1/CIP1 in hepatoma cells were examined. Two stably p21W...
In order to clarify critical events during bronchial carcinogenesis, and to evaluate a possible prog...
P21(Waf1/Cip1) is a potent cyclin-dependent kinase inhibitor. As a downstream mediator of p53, p21(W...
The Aggregatibacteractinomycetemcomitans cytolethal distending toxin (Cdt) induces lymphocytes to un...
p21(Waf1/Cip1) plays central roles in proliferation, differentiation, and apoptosis. Alterations in ...
AbstractAirway epithelium alterations, including squamous cell metaplasia, characterize smokers with...
Because the asthmatic bronchial epithelium is characterized by widespread damage, we postulated that...
Throughout development cells make the decision to proliferate, arrest or die. Control of this proces...
The first cyclin dependent kinase inhibitor to be discovered was the p21 cdk interacting protein (a....
Loss of cell cycle control is characteristic of tumorigenesis. The protein p21 is the founding membe...
p21WAF1/Cip1 belongs to the Cip/Kip family of cyclin kinase inhibitors (CKI) (p21Waf1/Cip1, p27Kip1,...
The p53-inducible gene product p21WAF1/CIP1 plays a critical role in regulating the rate of tumor in...
The p53-regulated gene product p21WAF1/CIP1 is the prototype of a family of small proteins that nega...
p21(Waf1/Cipl) is a critical downstream effector in the p53-dependent pathway of growth control and ...
The effects of exogenous expression of p21WAF1/CIP1 in hepatoma cells were examined. Two stably p21W...
In order to clarify critical events during bronchial carcinogenesis, and to evaluate a possible prog...
P21(Waf1/Cip1) is a potent cyclin-dependent kinase inhibitor. As a downstream mediator of p53, p21(W...
The Aggregatibacteractinomycetemcomitans cytolethal distending toxin (Cdt) induces lymphocytes to un...