Dynorphin(1-13), a long-lasting inhibitor of opiate receptor binding in vitro

The effect of dynorphin was determind on the binding of radioactive ¿, ¿ and k ligands to mouse brain P2 fractions in vitro. The Bmax of high affinity sites of each ligand was lowered and the Kd was raised for k ligands. This suggests that the mode of interaction of dynorphin with brain is complex and may involve a site that allosterically affects the binding sites of other opiates. © 1982.Peer Reviewe