Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-alpha targeting: first in-human results
- van Dam, Gooitzen M.
- Themelis, George
- Crane, Lucia M. A.
- Harlaar, Niels J.
- Pleijhuis, Rick G.
- Kelder, Wendy
- Sarantopoulos, Athanasios
- de Jong, Johannes S.
- Arts, Henriette J. G.
- van der Zee, Ate G. J.
- Bart, Joost
- Low, Philip S.
- Ntziachristos, Vasilis
Publication date
October 2011
DOIAbstract
The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-alpha (FR-alpha) in 90-95% of epithelial ovarian cancers prompted the investigation of intraoperative tumor-specific fluorescence imaging in ovarian cancer surgery using an FR-alpha-targeted fluorescent agent. In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-alpha-targeted fluorescent agent showcased the potential applications in patients with ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery
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