Rationale: Enhanced proliferation and impaired apoptosis of pulmonary arterial vascular smooth muscle cells (PAVSMCs) are key pathophysiologic components of pulmonary vascular remodeling in pulmonary arterial hypertension (PAH). Objectives: To determine the role and therapeutic relevance of HIPPO signaling in PAVSMC proliferation/apoptosis imbalance in PAH. Methods: Primary distal PAVSMCs, lung tissue sections from unused donor (control) and idiopathic PAH lungs, and rat and mouse models of SU5416/hypoxia-induced pulmonary hypertension (PH) were used. Immunohistochemical, immunocytochemical, and immunoblot analyses and transfection, infection, DNA synthesis, apoptosis, migration, cell count, and protein activity assays were performed in thi...
Pulmonary arterial hypertension (PAH) is a devastating disease characterised by progressive remodell...
International audienceBackground: Pulmonary hypertension (PH) is a devastating and progressive disea...
Enhanced proliferation of pulmonary arterial vascular smooth muscle cells (PASMCs) is a key patholog...
Rationale: Enhanced proliferation and impaired apoptosis of pulmonary arterial vascular smooth muscl...
RationaleEnhanced proliferation and impaired apoptosis of pulmonary arterial vascular smooth muscle ...
Rationale: The MSTs (mammalian Ste20-like kinases) 1/2 are members of the HIPPO pathway that act as ...
BackgroundEnhanced proliferation, resistance to apoptosis, and metabolic shift to glycolysis of pulm...
Summary: Pulmonary hypertension is a devastating disease characterized by excessive vascular muscula...
Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by the progressive...
International audienceRationale: Pulmonary arterial hypertension is characterized by vascular remode...
International audienceRATIONALE: Pulmonary arterial hypertension (PAH) is a progressive and fatal di...
The role of the Angiopoietin-1 (Ang1)-Tie2 pathway in pulmonary arterial hypertension (PAH) is contr...
Pulmonary arterial hypertension (PAH) is a rare multifactorial disease characterized by abnormal hig...
Pulmonary arterial hypertension (PAH) is a progressive lung disease diagnosed by an increase in pulm...
Background: The p38 Mitogen Activated Protein Kinase (MAPK) system is increasingly recognised as an ...
Pulmonary arterial hypertension (PAH) is a devastating disease characterised by progressive remodell...
International audienceBackground: Pulmonary hypertension (PH) is a devastating and progressive disea...
Enhanced proliferation of pulmonary arterial vascular smooth muscle cells (PASMCs) is a key patholog...
Rationale: Enhanced proliferation and impaired apoptosis of pulmonary arterial vascular smooth muscl...
RationaleEnhanced proliferation and impaired apoptosis of pulmonary arterial vascular smooth muscle ...
Rationale: The MSTs (mammalian Ste20-like kinases) 1/2 are members of the HIPPO pathway that act as ...
BackgroundEnhanced proliferation, resistance to apoptosis, and metabolic shift to glycolysis of pulm...
Summary: Pulmonary hypertension is a devastating disease characterized by excessive vascular muscula...
Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by the progressive...
International audienceRationale: Pulmonary arterial hypertension is characterized by vascular remode...
International audienceRATIONALE: Pulmonary arterial hypertension (PAH) is a progressive and fatal di...
The role of the Angiopoietin-1 (Ang1)-Tie2 pathway in pulmonary arterial hypertension (PAH) is contr...
Pulmonary arterial hypertension (PAH) is a rare multifactorial disease characterized by abnormal hig...
Pulmonary arterial hypertension (PAH) is a progressive lung disease diagnosed by an increase in pulm...
Background: The p38 Mitogen Activated Protein Kinase (MAPK) system is increasingly recognised as an ...
Pulmonary arterial hypertension (PAH) is a devastating disease characterised by progressive remodell...
International audienceBackground: Pulmonary hypertension (PH) is a devastating and progressive disea...
Enhanced proliferation of pulmonary arterial vascular smooth muscle cells (PASMCs) is a key patholog...