Leishmaniasis is a debilitating disease caused by the parasite Leishmania. There is extensive clinical polymorphism, including variable responsiveness to treatment. We study Leishmania donovani parasites isolated from visceral leishmaniasis patients in Nepal that responded differently to antimonial treatment due to differing intrinsic drug sensitivity of the parasites. Here, we present a proof-of-principle study in which we applied a metabolomics pipeline specifically developed for L. donovani to characterize the global metabolic differences between antimonial-sensitive and antimonial-resistant L. donovani isolates. Clones of drug-sensitive and drug-resistant parasite isolates from clinical samples were cultured in vitro and harvested for m...
Background: Protozoan Leishmania parasites are responsible for a range of clinical infections that r...
Leishmania donovani is the responsible agent for visceral leishmaniasis (VL) in the Indian subcontin...
Comparative metabolomics of Leishmania species requires the simultaneous identification and quantifi...
Leishmaniasis is a debilitating disease caused by the parasite Leishmania. There is extensive clinic...
Leishmaniasis is a debilitating disease caused by the parasite Leishmania. There is extensive clinic...
The post-genomics era has provided researchers with access to a new generation of tools for the glob...
Antimonial (sodium stibogluconate, SSG) resistance and differentiation have been shown to be closely...
Antimonial (sodium stibogluconate, SSG) resistance and differentiation have been shown to be closely...
Antimonial (sodium stibogluconate, SSG) resistance and differentiation have been shown to be closely...
Metabolomics-based studies are proving of great utility in the analysis of modes of action (MOAs) an...
Comparative genomic analyses of Leishmania species have revealed relatively minor heterogeneity amon...
Antimonial (sodium stibogluconate, SSG) resistance and differentiation have been shown to be closel...
Leishmania parasites multiply and develop in the gut of a sand fly vector in order to be transmitted...
<div><p>Comparative genomic analyses of <i>Leishmania</i> species have revealed relatively minor het...
Background: Protozoan Leishmania parasites are responsible for a range of clinical infections that r...
Leishmania donovani is the responsible agent for visceral leishmaniasis (VL) in the Indian subcontin...
Comparative metabolomics of Leishmania species requires the simultaneous identification and quantifi...
Leishmaniasis is a debilitating disease caused by the parasite Leishmania. There is extensive clinic...
Leishmaniasis is a debilitating disease caused by the parasite Leishmania. There is extensive clinic...
The post-genomics era has provided researchers with access to a new generation of tools for the glob...
Antimonial (sodium stibogluconate, SSG) resistance and differentiation have been shown to be closely...
Antimonial (sodium stibogluconate, SSG) resistance and differentiation have been shown to be closely...
Antimonial (sodium stibogluconate, SSG) resistance and differentiation have been shown to be closely...
Metabolomics-based studies are proving of great utility in the analysis of modes of action (MOAs) an...
Comparative genomic analyses of Leishmania species have revealed relatively minor heterogeneity amon...
Antimonial (sodium stibogluconate, SSG) resistance and differentiation have been shown to be closel...
Leishmania parasites multiply and develop in the gut of a sand fly vector in order to be transmitted...
<div><p>Comparative genomic analyses of <i>Leishmania</i> species have revealed relatively minor het...
Background: Protozoan Leishmania parasites are responsible for a range of clinical infections that r...
Leishmania donovani is the responsible agent for visceral leishmaniasis (VL) in the Indian subcontin...
Comparative metabolomics of Leishmania species requires the simultaneous identification and quantifi...