Copy number variation in obsessive-compulsive disorder and tourette syndrome : a cross-disorder study
- McGrath, Lauren M
- Yu, Dongmei
- Marshall, Christian
- Davis, Lea K
- Thiruvahindrapuram, Bhooma
- Li, Bingbin
- Cappi, Carolina
- Gerber, Gloria
- Wolf, Aaron
- Schroeder, Frederick A
- Osiecki, Lisa
- O'Dushlaine, Colm
- Kirby, Andrew
- Illmann, Cornelia
- Haddad, Stephen
- Gallagher, Patience
- Fagerness, Jesen A
- Barr, Cathy L
- Bellodi, Laura
- Benarroch, Fortu
- Bienvenu, O Joseph
- Black, Donald W
- Bloch, Michael H
- Bruun, Ruth D
- Budman, Cathy L
- Camarena, Beatriz
- Cath, Danielle C
- Cavallini, Maria C
- Chouinard, Sylvain
- Coric, Vladimir
- Cullen, Bernadette
- Delorme, Richard
- Denys, Damiaan
- Derks, Eske M
- Dion, Yves
- Rosário, Maria C
- Eapen, Valsama
- Evans, Patrick
- Falkai, Peter
- Fernandez, Thomas V
- Garrido, Helena
- Geller, Daniel
- Grabe, Hans J
- Grados, Marco A
- Greenberg, Benjamin D
- Gross-Tsur, Varda
- Grünblatt, Edna
- Heiman, Gary A
- Hemmings, Sian M J
- Herrera, Luis D
- Hounie, Ana G
- Jankovic, Joseph
- Kennedy, James L
- King, Robert A
- Kurlan, Roger
- Lanzagorta, Nuria
- Leboyer, Marion
- Leckman, James F
- Lennertz, Leonhard
- Lochner, Christine
- Lowe, Thomas L
- Lyon, Gholson J
- Macciardi, Fabio
- Maier, Wolfgang
- McCracken, James T
- McMahon, William
- Murphy, Dennis L
- Naarden, Allan L
- Neale, Benjamin M
- Nurmi, Erika
- Pakstis, Andrew J
- Pato, Michele T
- Pato, Carlos N
- Piacentini, John
- Pittenger, Christopher
- Pollak, Yehuda
- Reus, Victor I
- Richter, Margaret A
- Riddle, Mark
- Robertson, Mary M
- Rosenberg, David
- Rouleau, Guy A
- Ruhrmann, Stephan
- Sampaio, Aline S
- Samuels, Jack
- Sandor, Paul
- Sheppard, Brooke
- Singer, Harvey S
- Smit, Jan H
- Stein, Dan J
- Tischfield, Jay A
- Vallada, Homero
- Veenstra-VanderWeele, Jeremy
- Walitza, Susanne
- Wang, Ying
- Wendland, Jens R
- Shugart, Yin Yao
- Miguel, Euripedes C
- Nicolini, Humberto
- Oostra, Ben A
- Moessner, Rainald
- Wagner, Michael
- Ruiz-Linares, Andres
- Heutink, Peter
- Nestadt, Gerald
- Freimer, Nelson
- Petryshen, Tracey
- Posthuma, Danielle
- Jenike, Michael A
- Cox, Nancy J
- Hanna, Gregory L
- Brentani, Helena
- Scherer, Stephen W
- Arnold, Paul D
- Stewart, S Evelyn
- Mathews, Carol A
- Knowles, James A
- Cook, Edwin H
- Pauls, David L
- Wang, Kai
- Scharf, Jeremiah M
DOIAbstract
OBJECTIVE: Obsessive-compulsive disorder (OCD) and Tourette syndrome (TS) are heritable neurodevelopmental disorders with a partially shared genetic etiology. This study represents the first genome-wide investigation of large (>500 kb), rare (<1%) copy number variants (CNVs) in OCD and the largest genome-wide CNV analysis in TS to date. METHOD: The primary analyses used a cross-disorder design for 2,699 case patients (1,613 ascertained for OCD, 1,086 ascertained for TS) and 1,789 controls. Parental data facilitated a de novo analysis in 348 OCD trios. RESULTS: Although no global CNV burden was detected in the cross-disorder analysis or in secondary, disease-specific analyses, there was a 3.3-fold increased burden of large deletions previous...
Add to ORKG