Genome-wide association studies have identified 32 loci influencing body mass index, but this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-analyzed associations between ∼2.5 million SNPs and body fat percentage from 36,626 individuals and followed up the 14 most significant (P < 10-6) independent loci in 39,576 individuals. We confirmed a previously established adiposity locus in FTO (P = 3 × 10-26) and identified two new loci associated with body fat percentage, one near IRS1 (P = 4 × 10-11) and one near SPRY2 (P = 3 × 10-8). Both loci contain genes with potential links to adipocyte physiology. Notably, the body-fat-decreasing allele near IRS1 is associated with decreased IRS1 expression and with an ...
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic dis...
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic dis...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Genome-wide association studies have identified 32 loci influencing body mass index, but this measur...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
Recent genetic studies have identified alleles associated with opposite effects on adiposity and ris...
Recent genetic studies have identified alleles associated with opposite effects on adiposity and ris...
Recent genetic studies have identified alleles associated with opposite effects on adiposity and ris...
The genomic region ~500 kb upstream of IRS1 has been implicated in insulin resistance, type 2 diabet...
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic dis...
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic dis...
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic dis...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...
Genome-wide association studies have identified 32 loci influencing body mass index, but this measur...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
Recent genetic studies have identified alleles associated with opposite effects on adiposity and ris...
Recent genetic studies have identified alleles associated with opposite effects on adiposity and ris...
Recent genetic studies have identified alleles associated with opposite effects on adiposity and ris...
The genomic region ~500 kb upstream of IRS1 has been implicated in insulin resistance, type 2 diabet...
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic dis...
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic dis...
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic dis...
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic out...