Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid-Anchored Peptide Vaccines
- Koers, E.J.
- López-Deber, M.P.
- Weingarth, M.H.
- Nand, D.
- Hickman, D.T.
- Mlaki Ndao, D.
- Reis, P.
- Granet, A.
- Pfeifer, A.
- Muhs, A.
- Baldus, M.
DOIAbstract
Sensitivity is the key: Dynamic nuclear polarization NMR spectroscopy provides structural information on liposomal vaccines targeting Alzheimer's disease. DMPC/DMPG/Cholesterol mainly stabilizes extended structures of the lipid-anchored peptide, while in DMTAP/Cholesterol liposomes the peptide adopts a multitude of conformations including random-coil and extended structures
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