Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: The TREAT-OA consortium
- Kerkhof, Hanneke
- Meulenbelt, Ingrid
- Akune, Toru
- Arden, Nigel
- Aromaa, Arpo
- Bierma-Zeinstra, Sita
- Cooper, Charles
- Dai, J.
- Doherty, Michael
- Doherty, Sally
- Felson, D.
- Gonzalez, Antonio
- Gordon, A.
- Harilainen, Arsi
- Hart, D.J.
- Hauksson, Valdimar
- Heliovaara, Markku
- Hofman, Albert
- Ikegawa, S.
- Ingvarsson, Torvaldur
- Jiang, Q.
- Jonsson, H.
- Jonsdottir, Ingileif
- Kawaguchi, H.
- Kloppenburg, Margreet
- Kujala, Urho
- Lane, N.E.
- Leino-Arjas, Päivi I.
- Lohmander, Stefan
- Luyten, Frank
- Malizos, Konstantinos
- Nakajima, M.
- Nevitt, Michael
- Pols, Huib
- Rivadeneira Ramirez, Fernando
- Shi, D.
- Slagboom, Eline
- Spector, Timothy
- Stefansson, Kari
- Sudo, Akihiro
- Tamm, A.
- Tamm, Aile
- Tsezou, Aspasia
- Uchida, A.
- Uitterlinden, André
- Wilkinson, Mark
- Yoshimura, N.
- Valdes, Ana Maria
- Meurs, Joyce
- Carr, Andrew Jonathan
DOIAbstract
Objective: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. Methods: Descriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by creating various hip OA definitions in one large population based cohort (the Rotterdam Study
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